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Your Position: ホーム > latent GDF-8

latent GDF-8

概要

Name:Growth/differentiation factor 8
Target Synonym:MSTN,GDF-8,GDF8,Growth Differentiation Factor 8,MSLHP,Myostatin,Growth/Differentiation Factor 8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
GD8-M5243 Mouse Mouse latent GDF-8 Protein, His Tag
GD8-M5243-structure
GD8-M5243-sds
GD8-M82Q3 Mouse Biotinylated Mouse latent GDF-8 Protein, Avitag™,His Tag
GD8-M82Q3-structure
GD8-M82Q3-sds
GD8-H82Q3 Human Biotinylated Human Latent GDF-8 Protein, His,Avitag™
GD8-H82Q3-structure
GD8-H82Q3-sds
GD8-H8243 Human Biotinylated Human latent GDF-8 Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS & SPR verified)
GD8-H8243-structure
GD8-H8243-sds
GD8-H5343 Human Human Latent GDF-8 Protein, His Tag
GD8-H5243 Human Human latent GDF-8 Protein, His Tag (MALS verified)
GD8-H5243-structure
GD8-H5243-sds
ACRO Quality

生物活性データの一部

GD8-H8243-SPR
latent GDF-8 SPR

Human Follistatin Protein, His Tag, premium grade (Cat. No. FON-H52H4) immobilized on CM5 Chip can bind Biotinylated Human latent GDF-8 Protein, His Tag (Cat. No. GD8-H8243) with an affinity constant of 248 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
GD8-H5243-SPR
Latent GDF-8 SPR

Human Follistatin Protein, His Tag, premium grade (Cat. No. FON-H52H4) immobilized on CM5 Chip can bind Human latent GDF-8, His Tag (Cat. No. GD8-H5243) with an affinity constant of 364 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

latent GDF-8, GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8

Background

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Domagrozumab PF-6252616; PF-06252616 Pfizer Inc Details
AAV1-FS344 AAV1-Follistatin; AAV1-FS344 Phase 2 Clinical Nationwide Children'S Hospital Myositis, Inclusion Body; Muscular Dystrophy, Duchenne Details
RO-7204239 GYM-329; RO-7204239; RG-6237; RG-70240 Phase 3 Clinical F. Hoffmann-La Roche Ltd, Chugai Pharmaceutical Co Ltd Muscular Dystrophy, Facioscapulohumeral; Muscular Atrophy, Spinal Details
Apitegromab SRK-015 Phase 3 Clinical Scholar Rock Spinal Muscular Atrophies of Childhood; Neuromuscular Manifestations; Muscular Atrophy; Neuromuscular Diseases; Muscular Atrophy, Spinal; Atrophy Details
Talditercept alfa RO-7239361; BMS-986089; RG-6206; BHV-2000 Phase 3 Clinical Bristol-Myers Squibb Company Muscular Dystrophy, Duchenne; Neuromuscular Diseases; Muscular Atrophy, Spinal Details

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